Due to potential for fatal respiratory depression, do not administer promethazine and codeine concurrently to children Tier
Promethazine and codeine may perhaps induce marked drowsiness or may possibly impair the psychological and/or Actual physical talents necessary with the performance of doubtless hazardous responsibilities, such as driving a vehicle or working equipment.
This medication is additionally applied to take care of allergic skin reactions, offer sedation in individuals going through surgical methods, avoid and control nausea/vomiting just after surgical treatment, and forestall or address motion sickness. Manufacturer names for promethazine while in the U.S. consist of Phenergan and Promacot.
fentanyl intranasal and codeine both equally increase sedation. Prevent or Use Alternate Drug. Limit use to sufferers for whom choice procedure possibilities are insufficient
chlorpromazine will decrease the extent or result of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Keep track of. Helps prevent conversion of codeine to its active metabolite morphine
Children. Promethazine/codeine shouldn't be Utilized in any youngster more youthful than twelve decades of age or in a youngster younger than 18 yrs of age following a surgery to get rid of their tonsils or adenoids (tonsillectomy and/or adenoidectomy). Slow or shallow respiration that may result in Loss of life may well arise.
Extended-term usage of promethazine/codeine may well have an impact on your capacity to turn into pregnant or get a husband or wife pregnant. Speak with your Health care supplier For those who have any issues.
Choose this drugs only as directed by your health practitioner. Never acquire far more of it, don't take it more normally, and do not consider it for a longer time than your health care provider purchased. If far too much of the medication is taken for a very long time, it may develop into routine-forming and induce mental or physical dependence.
Making use of alcohol or tobacco with particular medicines can also lead to interactions to arise. The next interactions happen to be selected on The premise of their possible importance and therefore are not necessarily all-inclusive.
The narcotic antagonist, naloxone hydrochloride, may be administered when significant respiratory depression occurs with promethazine and codeine; any depressant outcomes of promethazine are certainly not reversed with naloxone. Diazepam may be utilised to regulate convulsions. Steer clear of analeptics, which can result in convulsions. Acidosis and electrolyte losses needs to be corrected. An increase in temperature or pulmonary problems may perhaps signal the necessity for establishment of antibiotic therapy.
The mix of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric clients fewer than six many years of age. Concomitant administration of promethazine products with other respiratory depressants has an association with respiratory melancholy, and often Demise, in pediatric people. The association does indirectly relate to individualized bodyweight-primarily based actavis promethazine with codeine dosing, which could normally permit safe administration.
Reserve concomitant prescribing of such medicine in sufferers for whom other cure selections are inadequate. Restrict dosages and durations towards the minimum amount required. Check closely for signs of respiratory despair and sedation.
Here are a few from the hazards of taking promethazine/codeine plus some recommendations on the Protected use of the medication.
A pharmacist can advocate an proper measuring gadget and can offer Recommendations for measuring the correct dose.